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DeCS
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Descriptor English:
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Checkpoint Kinase 1
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Descriptor Spanish:
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Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1)
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Descriptor Portuguese:
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Quinase 1 do Ponto de Checagem
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Synonyms English:
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Checkpoint-1 Kinase
Chk1 Kinase
Chk1 Protein Kinase
Protein Kinase, Chk1
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Tree Number:
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D08.811.913.696.620.682.700.143
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Definition English:
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A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle. |
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History Note English:
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2017 (2004)
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Allowable Qualifiers English:
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Record Number:
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56510
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Unique Identifier:
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D000071877
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Occurrence in VHL:
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Similar:
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DeCS
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